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October 2011 — In a study led by Dr. Daniela Rotin, Senior Scientist at SickKids and Professor of Biochemistry at the University of Toronto, mice were specially bred to lack the protein Nedd4L in the lungs. These mice developed lung disease similar to cystic fibrosis, including inflammation and obstructed airways. This study also confirmed a link between Nedd4L and increased transport of sodium across a membrane channel ENaC. In CF, increased sodium absorption contributes to the thick and sticky mucus that results in severe and chronic lung infections. More...
Reviewed/updated: 2011-11-01
