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Volunteer Advocate

Spotlight on Research


CHRONIC LUNG INFECTIONS INCREASE INFLAMMATION OVER TIME IN PEOPLE WITH CF

A team of researchers from across Canada and the US, including Cystic Fibrosis Canada-funded Dao Nguyen from McGill University, recently published their study on the impact of chronic lung infections on lung inflammation. Specifically, they looked at the role of Pseudomonas aeruginosa bacterial adaptations in promoting lung inflammation.

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Understanding bacterial interactions in lung infections in people with cystic fibrosis

Dr. Eric Bordeleau of the Geisel School of Medicine at Dartmouth and recipient of a Cystic Fibrosis Canada fellowship award in 2014 has spent the past year studying interactions between the different types of bacteria (the microbiome) involved in lung infections of infants and children with cystic fibrosis (CF). As part of Pr. George O’Toole’s laboratory, Dr. Bordeleau has pursued ways to grow and study bacterial interactions in the lab, enabling researchers to find out more about how to fight them in the human body. 

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Improving the Lives of People Depending on Transplants

For many people with cystic fibrosis (CF), lung transplantation offers hope for a second chance at life. CF is characterized by chronic lung infection and inflammation, which causes tissue damage over time. When the lungs have become damaged to the point that their function is severely reduced, lung transplant becomes the only option. Unfortunately, in Canada, the demand (or need) for viable donor lungs, and other organs, vastly outweighs the supply, with almost 4500 Canadians on transplant waiting lists (Canadian Organ Replacement Registry Annual Report, 2011).

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Dr. Shaf Keshavjee

Dr. Keshavjee is a Thoracic Surgeon and the Director of the Toronto Lung Transplant Program at Toronto General Hospital, University Health Network. With the development of the Toronto Ex Vivo Lung Perfusion System, Dr. Keshavjee has revolutionized lung transplants and helped improve health outcomes and quality of life for patients post lung transplant. Cystic Fibrosis Canada has supported Dr. Keshavjee since 1999, providing nearly $2.3 million in research funding.

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Advances in infection control lead to safer clinic spaces

Despite significant progress in treating cystic fibrosis (CF), lung infections caused by germs, such as bacteria, viruses, yeasts and molds, remain a serious problem for those with CF and can lead to worsening of the disease. The Infection Prevention and Control Guidelines contain recommendations to reduce the risk of CF patients receiving or spreading potential pathogens in the CF clinic or hospital setting. 

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Understanding interactions of bacteria in CF lungs

Dr. Michael Surette is a Cystic Fibrosis Canada funded-researcher, Professor and Research Chair in Interdisciplinary Microbiome Research at the Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University.

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